Speaker: Nirmal Mazumder, enseignant-chercheur au Département de Biophysique, India
Title: Label-free nonlinear optical microscopy for biomedical Research
Location: Salle ED38, bâtiment D, Faculté de Médecine – Teams link
Abstract: We developed a four-channel photon counting based Stokes polarimeter for spatial characterization of polarization properties of Second Harmonic (SH) light. In this way, the critical polarization parameters can be obtained concurrently without the need of repeated image acquisition. Various polarization parameters, including the degree of polarization (DOP), the degree of linear polarization (DOLP), and the degree of circular polarization (DOCP), are extracted from the reconstructed 2D Stokes vector based SH images in a pixel-by-pixel manner. The Stokes vector measurements are further extended by varying the polarization states of the incident light and recording the resulting Stokes parameters of the SH signal. In turn this allows the molecular structure and orientation of the samples including collagen fibers, skeletal muscle fiber, and starch granules. The combination of SHG microscopy and Stokes polarimeter hence makes a powerful tool to investigate the structural order of targeted specimens.
Biography: Dr. Nirmal Mazumder is an Associate Professor at the Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India. He obtained his Ph.D. in 2013 from Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei, Taiwan under the guidance of Prof. Fu-Jen Kao. From 2013 to 2016, he worked as a postdoctoral fellow at the University of Virginia, USA, and the Italian Institute of Technology, Genoa, Italy. He has been developing nonlinear optical microscopes, including two photon fluorescence, second harmonic generation, coherent anti-Stokes Raman scattering for biomedical applications. His research interests include development of microscopy-spectroscopy techniques, biomedical devices, biophotonics, smart materials, microfluidics and its biomedical applications. He has published more than 100 research articles in the peer-reviewed international journals, 11 books, 32 book chapters, and several poster/oral/invited presentations in National and International conferences. He have been recognized as scientists ranked in top 2 percentile by c-score in the sub-field for the year 2023, 2024. He is working on several national and bilateral research projects funded by Government of India as Principal Investigator. He is also working as the reviewer/guest editor/associate editors in several prestigious journals. He is the member of several national and international scientific societies and organizations including, the Optical Society (OPTICA) (Senior member), SPIE—the International Society for Optical Engineering (Senior member), Society of Biological Chemists (I) (Life Member), Environmental Mutagen Society of India (Life Member), Asian Polymer Association (Life Member), Indian Laser Association-ILA (Life Member), Research Society for the Study of Diabetes in India – RSSDI (Life Member).
Le séminaire de Nirmal Mazumder fait partie du programme interdisciplinaire MAT-PULSE (LUE).