Ph. D. Project
Title:
Characterization of Nanoparticles in Complex Media. Towards a Safety-by-Design Approach
Dates:
2019/10/01 - 2022/09/30
Supervisor(s): 
Other supervisor(s):
Dr CAPUTO Fanny (Fanny.Caputo@sintef.no)
Description:
This PhD thesis focuses on the safe development of efficient nanomaterials for medical applications, and more
precisely for drug delivery and medical device development. Those targeted applications of nanotechnology cover
a large spectrum of health challenges such as the increase of bioavailability, the change of biodistribution, the
increase of drug action, the stabilization of degradable drugs and the targeted delivery of drugs. But the potential
risks are much more difficult to be assessed. One of them deals with the characterization of nanoparticles in
complex media. Current techniques used to measure the physicochemical characteristics of nanoparticles in
simple media are poorly predictive of their behavior observed during in vivo experiments . As a consequence,
some pharmacokinetic or toxicokinetic issues are detected too late. In this PhD framework, two main issues are
addressed:
• optimizing and validating standards of protocol associated with the current characterization approaches with
respect to the analytical Quality-by-Design guidelines (ICH Q2) recommended by FDA and EMA. The objective is to
efficiently control the inter-lab quality of results;
• developing an innovative characterization process that could be used in any laboratory with different
categories of measurement technologies.
Keywords:
Nanomedecine, Quality-by-Design, Characterization, Complex Media, Protein Corona
Conditions:
This PhD would be financed by a 3-years CIFRE contract for applied research. CYBERnano will be the industrial
partner for the CIFRE application and will provide the financial support but also its experience in Quality-by-
Design and the application to real cases in nanomedicine. T. Bastogne and M. Barberi-Heyob will provide their
scientific support for the statistical and biological expertise in nanomedicine while F. Caputo will bring its skills and
experience in the physico-chemical characterization of nanomaterials.
Department(s): 
Biology, Signals and Systems in Cancer and Neuroscience
Funds:
CIFRE