BioSiS / Department Biology, Signals and Systems in Cancer and Neuroscience

In oncology, a first project concerns the identification of strategic molecular targets. In response to the therapeutic resistance of metastatic breast cancer, this project aims to improve management by predicting therapeutic escape through the characterization of the molecular mechanisms that regulate the activity of biomarkers such as claudine 1, DDB2 and ERa36 and their coding gene.

The second project concerns the field of theranostics in biophotonics, in which we hope that the laboratory will become a major and clearly identifiable actor at the national and international levels. Biophotonics is the application of optics to biology in basic research, diagnosis and biomedical intervention. It is a multidisciplinary field that covers photonics, multi-scale biology and engineering (instrumentation, signal and image processing, systems). This cutting-edge field, which includes all optical analysis techniques for biological processes, has seen very strong growth in recent years, supported by a series of technological advances in the field of lasers, fluorescent marking of biomolecules, nanomedicines and dedicated instrumentation;

In a unique project, we are bringing together the therapeutic strategies we are developing in nanomedicine and our approaches in photodiagnostics through clinical spectroimaging methods (optical biopsy & multimodality panoramic imaging) around radiation-tissue interactions. The objectives are to obtain a label from the League against Cancer and to increase our international visibility.

In neuroscience, work on the study of the brain mechanisms of visual recognition in humans through the identification and localization of cognitive networks will be strengthened. These studies will benefit from the simultaneous recording of surface EEG - depth EEG (SEEG), with the ability to simultaneously record the neurophysiological activity of the unit neuron (in collaboration with Center for Systems Neurosciences - Leicester) which is a specificity of CRAN. The rapid periodic stimulation approach, which focuses on visual function, is key to intelligibly linking signals recorded at different levels of brain organization and in different modalities. We wish to make progress on multi-scale numerical and biophysical modelling by establishing relationships between the cellular scale and the scale of neuron populations. Essential local resources in signal/image processing and modelling, within CRAN but more broadly in the Charles Hermite Federation, will contribute to this success. This multidisciplinary research theme opens up opportunities for collaboration in many fields (neuropsychiatry, neurodegenerative diseases, etc.).

These projects in oncology and neuroscience benefit from a methodological research activity in signal and image processing (source separation, image restoration, etc.) with applications in optical spectroscopy, spectroimaging and microscopy. The main themes are the parsimonious regularization of inverse problems and multidimensional problems, namely hyperspectral image processing and tensor approaches.

  • Molecular targets in a translational approach
  • Interactions between radiation and biological tissue
  • Neurosciences of systems and cognition
  • Multidimensional signals
Last publications [+]
Thierry Bastogne, Fanny Caputo, Adriele Prina-Mello, Sven Borgos, Muriel Barberi-Heyob. A state of the art in analytical quality-by-design and perspectives in characterization of nano-enabled medicinal products. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2022, 219, pp. 114911  [+]
Marine Geoffroy, Marine Lemesle, Alexandra Kleinclauss, Sabine Mazerbourg, Levy Batista, Muriel Barberi-Heyob, Thierry Bastogne, Wilfrid Boireau, Alain Rouleau, Dorian Dupommier, Michel Boisbrun, Corinne Comoy, Stéphane Flament, Isabelle Grillier-Vuissoz, Sandra Kuntz. AB186 inhibits migration of triple-negative breast cancer cells and interacts with α-Tubulin. International Journal of Molecular Sciences, MDPI, 2022, 23, pp. 6859  [+]
Thierry Bastogne. iQbD: a TRL-indexed quality-by-design paradigm for medical device engineering. Journal of Medical Devices, American Society of Mechanical Engineers (ASME), 2022, 16, pp. 021008  [+]
Diane Rekow, Jean yves Baudouin, Renaud Brochard, Bruno Rossion, Arnaud Leleu. Rapid neural categorization of facelike objects predicts the perceptual awareness of a face (face pareidolia). Cognition, Elsevier, 2022, 222, pp. 105016  [+]
Omar Zenteno, Dinh-Hoan Trinh, Sylvie Treuillet, yves Lucas, Thomas Bazin, Dominique Lamarque, Christian Daul. Optical biopsy mapping on endoscopic image mosaics with a marker-free probe. Computers in Biology and Medicine, Elsevier, 2022, 143, pp. 105234  [+]
Laurence Schenone, Caroline Houillier, Marie Laure Tanguy, Sylvain Choquet, Kossi Agbetiafa, Hervé Ghesquières, Gandhi Damaj, Anna Schmitt, Krimo Bouabdallah, Guido Ahle, Remy Gressin, Jérôme Cornillon, Roch Houot, Jean-Pierre Marolleau, Luc-Matthieu Fornecker, Olivier Chinot, Frédéric Peyrade, Reda Bouabdallah, Cécile Moluçon-Chabrot, Emmanuel Gyan, Adrien Chauchet, Olivier Casasnovas, Lucie Oberic, Vincent Delwail, Julie Abraham, Virginie Roland, Agathe Waultier-Rascalou, Lise Willems, Franck Morschhauser, Michel Fabbro, Renata Ursu, Catherine Thieblemont, Fabrice Jardin, Adrian Tempescul, Denis Malaise, Valérie Touitou, Lucia Nichelli, Magali Le Garff-Tavernier, Aurélie Plessier, Philippe Bourget, Caroline Bonmati, Sophie Wantz-Mézières, Quentin Giordan, Véronique Dorvaux, Cyril Charron, Waliyde Jabeur, Khê Hoang-Xuan, Luc Taillandier, Carole Soussain. Intensive chemotherapy followed by autologous stem cell transplantation in primary central nervous system lymphomas (PCNSLs). Therapeutic outcomes in real life-experience of the French network. Bone Marrow Transplantation, Nature Publishing Group, 2022, 57, pp. 966-974  [+]